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These therapeutic effects appear to be mediated through curcumins modulation of key neuromodulators, with particularly noteworthy differential regulation observed between brain and gut tissues: while BDNF and phosphorylated CREB (p-CREB) levels increased in hippocampal tissue, their expression decreased in colonic tissues (Yu et al., 2015)

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Next, exosomes were isolated from the culture medium and subsequently administered intravenously to MitoPark mice, a transgenic Parkinsons disease model with a conditional knockout of mitochondrial transcription factor A (MTFA) in dopaminergic neurons