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The affected patients may present loss of elasticity and tightness of the skin in a localized area, or it can be systemic, manifesting around the lips with microstomia, eating and speaking limitations, or in the fingers with sclerodactyly and vascular complications leading to functional impairment [94]

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n-dodecyl -D-glucopyranoside

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Injections provide higher blood concentrations than oral supplements due to their direct route into the bloodstream which allows for greater absorption rates resulting in more effective results with fewer doses required over time compared with oral supplements