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Okorie OE, Ko SH, Go S, Lee S, Bae JY, Han K, et al

Exposure to a number of stressors, including electrophiles, reactive oxidative species, heavy metals, and xenobiotics leads to conformational changes in Keap1, enabling stabilization and nuclear accumulation of Nrf2, where it coordinates the expression of multiple cellular defense enzymes, such as NAD(P)H:quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HO-1), and key components of the glutathione (GSH) and thioredoxin (TXN) antioxidant systems 2

The word eicosanoid arises from the Greek root meaning twenty, and the term classically refers to unbranched 20-carbon molecules derived from arachidonic acid oxygenation

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Ann Oncol 36(5):543-547, 2025