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Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

Instead of simply appending a non-a-amino long straight chain amino acid to the N-terminal we chose to eliminate the N-terminal amine entirely, which increased overall hydrophobicity and removed a critical hydrogen bonding site

Kato et al

Epithalon is a synthetic version of a naturally occurring peptide derived from the pineal gland , a key regulator of aging and circadian rhythm

Consistent administration allows proper assessment
