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Studies have shown that after treatment with modified Gegen Qinlian decoction and its metabolites baicalein, berberine and glycyrrhizic acid, the activity of diamine oxidase and D-lactic acid in serum significantly decreased, and the levels of ZO-1, occludin, and claudin 1 in colon tissues increased, suggesting that the therapeutic effect of modified Gegen Qinlian decoction may be related to a reduction in intestinal permeability [94]

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At the general level, this dual (modulatory) action (i.e., either hypertension or hypotension reversed toward normal blood pressure) applies to the NO-systems effects as a whole, as well [11,29]