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Widely used for type 2 diabetes mellitus and obesity, GLP-1RAs may increase risk for injection-site reactions.
Acarbose, an AGI, has been shown in pre-clinical models to increase lifespan (greater longevity benefits in males), with decreased body weight gain independent of calorie intake reduction

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GLP1R-based obesity therapies can reduce lean muscle and energy expenditure via adaptive thermogenesis (also known as metabolic adaptation), leading to weight plateaus and regain

These metabolites help support gut barrier integrity, digestive resilience, and healthy metabolic signaling
