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Sites of protease/peptidase vulnerabilities in GLP-1 were removed by amino acid substitution and the peptide backbone was bis-lipidated to promote MEDI7219 reversible plasma protein binding without affecting potency

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Following functional endoscopic sinus surgery, adults with chronic rhinosinusitis with nasal polyps and obesity had a lower risk for revision surgery if they were prescribed a GLP-1 receptor agonist, according to study results.These data were published in Otolaryngology-Head and Neck Surgery.

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