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Many signalling molecules found in the periphery are also used within the brain

Heatmap and principal component analysis (PCA) demonstrated significant differences between the GLP-1 ON and GLP-1 OFF RNA-seq results ( S6B and S6C Fig )

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Similarly, physiological increases in GLP-2 with refeeding increase villus length and crypt-cell proliferation in an epithelial-IGF-dependent manner 52