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Source: Psychonautwiki Exendin-4 and exenatide are agonists, so they activate the GLP-1 receptor

Early data show that if a patient has been highly successful with GLP-1s, they are likely to be highly successful with weight-loss surgery because they work through many of the same mechanisms

PLoS One 7, e32675

According to FDA prescribing information, nausea occurs in 1544% of patients depending on the specific agent and dose, with vomiting, diarrhea, constipation, and abdominal pain also frequently reported

The specific effects of GLP-1R agonism on food avoidance, food aversion and emetic behaviors have been delineated more clearly in recent years

Diabetes 59(7):17651770