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Although no clinical trials have examined the impact of GLP-1RAs on Huntingtons disease (HD), more and more evidence in animal models is looking promising (Duarte et al., 2018)

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NPY neurons, also known to express AgRP, were inhibited by semaglutide, suggesting disinhibition of AgRP signaling to the PB, resulting in increased activation of this nucleus

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Your provider can slow the titration schedule, prescribe a lower maintenance dose, recommend supportive measures for side effects, or consider alternative medications based on your individual needs

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